The P.L.E.A.S.E.^® - platform

P.L.E.A.S.E.® (Painless Laser Epidermal System) is a novel transdermal delivery method for high molecular weight drugs. A handheld laser device creates controlled aqueous micropores in the epidermis. Due to the special features of the device the micropores do not reach the dermis, where nerves and blood vessels reside. An intelligent graphical user interface guarantees simple and safe use by the medical personnel or the patient, who can use the device without supervision

View P.L.E.A.S.E.® Animation Video

Detailed description of micropore formation

A special laser source ablates outer skin tissue painless in a highly controlled and accurate fashion.

• Short pulses practically eliminate thermal damage
• No carbonisation, only fast ablation of skin tissue
• Very accurate skin ablation in 5-10 µm steps
• Variable laser deflection allows flexible formation of pore arrays

The P.L.E.A.S.E.^® - device allows fine tuning of pore properties (number and depth) to a therapeutic need for a specific drug dose.