Pantec Biosolutions developed a novel platform for transdermal delivery of large molecule drugs. Although transdermal application of drugs is a very powerful administration route, there are still very few patches on the market. The reason for this is that only a few molecules are able to pass the outer skin layers passively to finally reach the blood capillaries in the dermis. The outermost layer, the stratum corneum in particular, provides a strong barrier for molecules larger than 500 Dalton. So pretreating skin with microporation is a route to effect successful transdermal delivery of larger proteins and any other drug molecule.
Pantec Biosolutions' proprietary laser- powered P.L.E.A.S.E.® extends the range of drugs that can be delivered transdermally. This novel application allows both low and high molecular weight drugs to be delivered directly into the various layers of the skin.
In collaboration with leading patch development and manufacturing companies, Pantec Biosolutions has developed a skin patch technology for use with P.L.E.A.S.E.® in the delivery of large molecule proteins used for In Vitro Fertilisation (IVF) and other applications.