P.L.E.A.S.E.® is Pantec Biosolutions’ platform for the transdermal delivery of large molecule drugs. Although transdermal application of drugs is a very powerful administration route, there are still very few patches on the market. The reason for this is that only a few molecules are able to pass the outer skin layers passively to finally reach the blood capillaries in the dermis.
The outermost layer, the stratum corneum in particular, provides a strong barrier for molecules larger than 500 Dalton. So pretreating skin with microporation should be a route to effect successful transdermal delivery of larger proteins in patches. From transdermal to intraepidermal drug delivery using Pantec Biosolutions' proprietary laser- powered P.L.E.A.S.E.® extends the range of drugs that can be delivered transdermally. This novel application allows both low and high molecular weight drugs to be delivered transdermally.