Intradermal delivery

Precise and stable delivery of siRNA and other biological compounds

Skin scar keloids are dermal fibroses due to excessive expression of the protein CTGF (connective tissue growth factor). Gene silencing was shown by our collaboration partner RXi Pharmaceuticals with their proprietary molecule sd-rxRNA™ in vivo. This has the limitation that the siRNA must currently be injected into scars, which is very painful. P.L.E.A.S.E. provides a less invasive and less painful method of delivery.

In vitro skin experiments show qualitative evidence for dermal siRNA delivery following skin microporation. Cellular transfection patterns appear comparable to those obtained by intradermal injection.